Further Refinement of Carboplatin Dosing

Further refinement of carboplatin dosing.

Administration of a drug to a patient carries with it the implicit assumption that the drug will produce some beneficial effect in that patient although there is no guarantee that the dose selected will actually produce any observable effect. In reality, the consequences of drug administration can be either favorable, and defined clinically as therapeutic, or unfavorable, and defined clinically...

Carboplatin Dosing for Adult Japanese Patients

Carboplatin is a platinum-based anticancer drug that has been long used to treat many types of solid cancer. Because the clearance of carboplatin strongly correlates with the glomerular filtration rate (GFR), its dosage is calculated with the Calvert formula on the basis of the patient's GFR to achieve the target area under the plasma drug concentration-time curve (AUC) for each patient. Howeve...

A Further Refinement of Mordell’s Bound on Exponential Sums

Further refinement of pairing computation based on Miller's algorithm

In 2006, Blake, Murty and Xu proposed three refinements to Miller’s algorithm for computing Weil/Tate Pairings. In this paper we extend their work and propose a generalized algorithm, which integrates their first two algorithms. Our approach is to pre-organize the binary representation of the involved integer to the best cases of Blake’s algorithms. Further, our refinement is more suitable for ...

Further refinement of the Usher 2A locus at 1q41.

Usher syndrome (USH) is characterised by congenital sensorineural hearing loss and progressive pigmentary retinopathy. All three subtypes (USH1, USH2, and USH3) are inherited as recessive traits. People with Usher type 2 (USH2) have normal vestibular responses and moderate to severe hearing loss. These syndromes have been found to be genetically heterogeneous, with a single locus for USH2 at 1q...